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doi: 10.1002/cnr2.1728 149 Montero-OvalleWSanabria-SalasMCMesa-Lpez de MesaJVarela-RamrezRSegura-MorenoYYSnchez-VillalobosSAet al

Progesterone receptor modulator-associated endometrial changes (PAEC) have been found to occur in 0.4% of patients using UPA while 41%78.8% of patients who developed PAEC appeared to be reversible upon discontinuing UPA ( Aromatase inhibitor is used to block the action of aromatase, an enzyme that is responsible for the conversion of androstenedione to estrogen, resulting in increased cell proliferation and fibrosis

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Persistent ER stress promotes the extensive release of Ca 2+ into the cytoplasm via the IP3R channel

Light exposure accelerates this pathway significantly